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After propensity matching with age, gender and CTP score, there was a significant mortality reduction from AR cirrhosis etiology among those with CTP B and active bleeding or CTP C (n=199, ATET -0.23, 95% CI -0.35, -0.10, p 7 (n=272, ATET -0.16, 95% CI -0.31, -0.01, p =0.04)

Rather than simply co-administering two separate peptides, the team designed tirzepatide on the native GIP(1-42) backbone, then introduced specific amino acid substitutions at key positions to confer GLP-1 receptor cross-reactivity [6]

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This increase in IGF-1 is responsible for benefits such as neuroprotection, cell survival, and tissue regeneration, but GHRP-6 also acts directly to modulate immune responses, stimulate appetite, and influence other hormones and signalling pathways